Optimized Health & Longevity Require Pre-adult intervention

Help Your Children Reach Their Full Potential -
in Health, Happiness, Resilience, and
Lifelong Wellbeing.

The time before adulthood, from preconception through pregnancy, infancy, childhood, and adolescence, is a critical window during which lifelong patterns of health and development are established. This period is marked by uniquely high levels of adaptability in the body and brain, during which environmental influences (the exposome) can have lasting impacts within the boundaries of our genes.

Pre-adult Healthspan Interventions (PHI) are the descriptively-named core of an eponymous strategy for identifying, evaluating, and disseminating all known and suspected factors that, if applied early, will optimize adult attributes.

The goal is to help every new human optimize their physique and cognition, and maximize their innate immunity, resilience, and natural lifespan, as means for improving health and quality of life across generations. Many physical structures and epigenetic settings are especially plastic in pre-adulthood, but become persistent as the individual matures.

Why PHI Matters and How Do We Achieve This?

Most common risks and boosters during pregnancy and early life are already well-managed. There remain, however, innumerable simple, safe, and effective interventions that are inadequately proven, unfamiliar, unknown or unavailable to care providers, or otherwise bypassed. Paradoxically, an aging cell phone or computer is connected to significant guidance about almost every imaginable concern, but the right answers rarely pop up on the first try, and you cannot be sure that what you find is the last word on the matter.

The PHI Program organizes a trove of curated information, in a way that offers summary and detailed responses to every query, including warnings, counterpoints and links, in whatever language is chosen, at no cost to users. Besides an ever-growing source of answers, there is a blog for communication with other users, links to product and service sources, as well as with PHI Program staff members who maintain the site.

The PHI Program also includes advocacy for worldwide implementation, and for research that supports early cultivation of immunity, mental health, physical growth, resilience, cognitive capacity, productivity, and even long-term longevity.

Amazing modern interventions like gene therapies and prenatal surgeries are important and included in the PHI program. Accessible PHI, wisely deployed, can often obviate the need for costly high-tech answers, and should be explored first unless the situation is urgent. There are many low-cost, highly proven, gentle, non-invasive and accessible interventions against disease, but reactionary rejection of modern remedies serves no one.

What’s needed is a coordinated global effort to:

• Create a free, online, multilingual PHI database - one that explains what works, how it works, and who it helps.

• Test and validate simple interventions for safety, effectiveness, and synergies.

• Recognize promising PHI from diverse fields like folk medicine, mental health, pediatrics, sports science, aesthetics, and even veterinary care.

• Include pregnant women and children in long-term studies, to better understand how early interventions shape health outcomes.

• Promote PHI globally with clear, science-backed health messaging.

Addressing The Gaps

Despite their promise, many effective PHIs go unnoticed or unused. Common barriers include:

• Lack of clear identification and application guidance.

• Limited personalization or tailoring for different populations.

• Low awareness among professionals, caregivers, and families.

• Inadequate financial incentive for companies to promote or research them.

Because of this, valuable early-life opportunities are often missed, resulting in poorer outcomes that become harder (and more expensive) to fix later. Early anatomical and physiological development shapes future potential. When overlooked, the consequences can last a lifetime.

Ethical Research and Safe Exploration

Research involving children and pregnant individuals must be handled with the greatest of care. But avoiding such research entirely is also unethical. Missed opportunities for improvement carry a cost. Ethical and safe study designs, such as retrospective studies, conservative dosing, and enhanced monitoring can make this research possible without compromising safety.

There is growing interest in how paternal factors affect pre-adulthood outcomes. A father’s diet, stress, age, and environmental exposures can influence the epigenetics of sperm, with downstream effects on offspring health (Carone et al., 2010; Soubry et al., 2016).

Who Should
Be Involved?

The success of PHI depends on collaboration between:

• Governments and health departments

• Public health and school systems

• Medical societies and research institutions

• Charitable foundations and international organizations like WHO and the NHS and CDC

• Major health conferences (such as the Exposome Moonshot, Woods et al., 2025) can help bring PHI to the forefront and spark meaningful investment.

Priority Actions
to Advance PHI:

1. Include pregnant individuals and children in health studies, with long-term tracking of outcomes.

2. Develop a free, easy-to-navigate, multilingual online PHI resource, listing all preventive and supportive strategies with evidence, usage guidelines, side effects, and alternative viewpoints.

3. Support obstetric and paediatric clinics in identifying and studying PHI, with outcome tracking and professional engagement.

The PHI team.

Sascha Landskron

Walter Crompton

Dr Tamara Pheiffer

is a Registered Dietitian with over 20 years of clinical experience, working with people of all ages, specialising in: pediatric eating disorders and ARFID, nutritional genetics, nutrition for mental health and therapeutic ketogenic diets.

Sascha is registered with the British Dietetic Association (BDA) and the UK Health and Care Professions Council (HCPC). She collaborates with clinics around the UK, and lectures at several UK universities on food allergies, feeding and eating problems and nutritional genetics.

Originally from Canada, Sascha has lived in several countries and now resides in the UK with her husband and their two children, where they enjoy spending active time outdoors. She sees healthspan as the roadmap for people to achieve their individual personal best.

is a longevity activist, nominally retired from a biomedical engineering career. Study of work from the Conboy Lab at UC Berkeley led to a realization that important pre-adult health and longevity interventions were being under-appreciated.

Additional investigation massively confirmed the initial finding, leading to a huge and ever-growing collection of proven and prospective interventions. Support from many sides kept the flame alive, especially the assertive voluntary involvement by Sascha and Tamara. Born of Canadian parents, he spent the majority of his “pre-adult” life in the lovely Finger Lakes district of New York, settling in California after college.

Walt resides in suburban San Mateo with Nancy, with whom he shared the raising of eight kids (mostly foster children). Their yard overflows with unusual fruit trees and loud chickens. He views unlimited vitality as the most important humanitarian cause, and dreams of a kaleidoscope of new careers if age-related degeneration and the cycle of pain and hatred it engenders are overcome.

is a global leader in medical futurism and longevity medicine, with over a decade of expertise in biogerontology, functional and molecular medicine, and healthcare innovation across Africa and beyond. She serves as Chief Science and Research Officer for Afrolongevity, where she collaborates with international experts like Dr Aubrey de Grey and Prof Evelyn Bischof, and sits on the ILA Medical Scientific Board.

Dr Tamara has trained over 10,000 health professionals in cutting-edge approaches to healthspan extension. Her work has featured on national TV and radio, and in leading publications including Longevity, Mail & Guardian, and Health Intelligence.

She holds postgraduate qualifications in epigenetics, nutrigenomics, and functional medicine, and is currently completing further degrees in biotechnology and biogerontology. In 2026, she will begin PhD candidacy in Biomedical Science and continue her international lecturing in the fields of youth extension and biological age reversal.

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